Challenge

Knapsack Problem

Gene cluster analysis: Understanding genetic diseases.

Overview

The area of Knapsack problems is one of the most active research areas of combinatorial optimization.

The problem is to maximise the value of items placed in a knapsack given the constraint that the total weight of items cannot exceed some limit.

Example

For our challenge, we use a version of the knapsack problem with configurable difficulty, where the following two parameters can be adjusted in order to vary the difficulty of the challenge:

  • Parameter 1: num_itemsnum\_items is the number of items from which you need to select a subset to put in the knapsack.
  • Parameter 2: better_than_baseline1better\_than\_baseline \geq 1 is the factor by which a solution must be better than the baseline value.

The larger the num_itemsnum\_items, the more number of possible SknapsackS_{knapsack}, making the challenge more difficult. Also, the higher better_than_baselinebetter\_than\_baseline, the less likely a given SknapsackS_{knapsack} will be a solution, making the challenge more difficult.

The weight wjw_j of each of the num_itemsnum\_items is an integer, chosen independently, uniformly at random, and such that each of the item weights 1wj501 \leq w_j \leq 50, for j=1,2,...,num_itemsj=1,2,...,num\_items. The values of the items vjv_j are similarly selected at random from the same distribution.

We impose a weight constraint W(Sknapsack)0.5W(Sall)W(S_{knapsack}) \leq 0.5 \cdot W(S_{all}), where the knapsack can hold at most half the total weight of all items.

Consider an example of a challenge instance with num_items=6num\_items=6 and better_than_baseline=1.09better\_than\_baseline = 1.09. Let the baseline value be 100:

weights = [48, 20, 39, 13, 25, 16]
values = [24, 42, 27, 31, 44, 31]
max_weight = 80
min_value = 109

The objective is to find a set of items where the total weight is at most 80 but has a total value of at least 109. Now consider the following selection:

selected_items = [1, 3, 4, 5]

When evaluating this selection, we can confirm that the total weight is less than 80, and the total value is more than 109, thereby this selection of items is a solution:

  • Total weight = 20 + 13 + 25 + 16 = 74
  • Total value = 42 + 31 + 44 + 31 = 148

Our Challenge

In TIG, the baseline value is determined by a greedy algorithm that simply iterates through items sorted by value to weight ratio, adding them if knapsack is still below the weight constraint.

Applications

The Knapsack problems have a wide variety of practical applications. The use of knapsack in integer programming led to breakthroughs in several disciplines, including energy management and cellular network frequency planning.

Although originally studied in the context of logistics, Knapsack problems appear regularly in diverse areas of science and technology. For example, in gene expression data, there are usually thousands of genes, but only a subset of them are informative for a specific problem. The Knapsack Problem can be used to select a subset of genes (items) that maximizes the total information (value) without exceeding the limit of the number of genes that can be included in the analysis (weight limit).

Microarray clustering of differentially expressed genes in blood

Figure 1: Microarray clustering of differentially expressed genes in blood. Genes are clustered in rows, with red indicating high expression, yellow intermediate expression and blue low expression. The Knapsack problem is used to analyse gene expression clustering.